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The Human Energy CenterFenton LeBon, MD • nanoNAD+™
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Nanotechnology
6 min read•Archived in NAD_Research_Packet.pdf & Dallas2.json

Dermal Bioenergetics: Overcoming Photo-Aging with Single-Molecule Topical NAD+

Extrinsic photo-damage accounts for 97% of visible skin aging by driving fibroblast senescence. How topical 1.92 nm nanoNAD+ fuels dermal cellular machinery and collagen restoration.

“Research indicates extrinsic factors account for approximately 97% of aging-related skin changes. Normal age-related NAD+ decline leads directly to fibroblast senescence and extracellular matrix collapse.”

— Dr. Fenton LeBon, MD, MBA

Core Scientific Takeaways

  • Extrinsic ultraviolet radiation and environmental oxidants trigger fibroblast senescence.
  • Senescent fibroblasts secrete matrix metalloproteinases (MMPs) that actively digest dermal collagen.
  • 1.92 nm single-molecule nanoNAD+ penetrates the stratum corneum to deliver direct energetic support to dermal fibroblasts.

Rescuing the Dermal Fibroblast

When UV radiation damages fibroblast DNA, cellular NAD+ is exhausted. Senescent fibroblasts secrete MMP-1, breaking down collagen scaffolding. nanoNAD+™ penetrates epidermal pores to supply the cofactor needed for SIRT1 deacetylation, extinguishing the senescence-associated secretory phenotype (SASP) and stimulating new collagen formation.

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