⚡
The Human Energy CenterFenton LeBon, MD • nanoNAD+™
Complete Curriculum

The Teachings Library

Explore Dr. Fenton LeBon's definitive compendium on human cellular bioenergetics. Every teaching is indexed directly from his clinical recordings, laboratory research dossiers, and peer-reviewed citations.

Category:
Peptides & Blueprints8 min read

Peptides: The Blueprint — Instructions That Tell Your Cells What To Do

Dr. LeBon's three-part biological hierarchy: Food is the bricks and mortar, NAD+ is the energy that runs the cement mixer, and Peptides are the blueprints that instruct cells how to build and heal.

•The Three Pillars: Food = Bricks & Mortar; NAD+ = Energy running the cement mixer; Peptides = Architectural Blueprints.
•Mitochondrial Problem 1 (Holes in inner membrane): SS-31 (Elamipretide) binds cardiolipin to seal holes and restore ATP.
Source: Peptides_The_Blueprint_Data.txt & NAD_Reference_Packet_Aug2026.txtExplore Teaching
Bioenergetics9 min read

What Is It Like to Feel, 'I Have Energy'? Interoception, AMPK vs. mTORC1 & The Biology of Vitality

Dr. LeBon's philosophical and biological inquiry into the subjective human experience of having energy: distinguishing physical capacity and catecholamine arousal from interoceptive cellular energy sensing.

•Subjective energy is distinct from objective physical capacity: a person feels energetic or depleted before work is performed.
•Subjective energy is distinct from wakefulness or catecholamine arousal: one can be calm while feeling deeply energetic, or alert while depleted.
Source: What_Is_It_Like_To_Feel_Energy.txtExplore Teaching
Molecular Purity7 min read

The Upstream NAD-Glutathione Axis: Why Glutathione Requires Hydride Loading

Why glutathione sits downstream of NAD+ in the biochemical hierarchy, why taking glutathione alone fails in older adults, and Dr. LeBon's Columbia University pathway diagrams.

•NAD+ sits upstream of glutathione in the antioxidant hierarchy.
•Glutathione cannot function until it is 'loaded' with a high-energy hydride ion (H-), which depends on NAD+/NADPH.
Source: NAD_Reference_Packet_Aug2026.txt & Clinical Discussion NotesExplore Teaching
Nanotechnology7 min read

Dermal Regeneration: The Synergy of Topical nanoNAD+, SIRT3-SOD2 & GHK-Cu Copper Peptides

The molecular convergence of single-molecule 1.92 nm nanoNAD+ and GHK-Cu copper peptides in reversing dermal senescence, stimulating collagen, and activating mitochondrial SOD2.

•Extrinsic UV radiation drives fibroblast senescence and the destructive Senescence-Associated Secretory Phenotype (SASP).
•Restoration of NAD+ activates SIRT3, which deacetylates and activates manganese superoxide dismutase (SOD2).
Source: NAD_Research_Packet.pdf (Expanded Section 4) & PTL DLS ReportExplore Teaching
Bioenergetics6 min read

The Crude Oil & Refinery Hierarchy: Why NAD+ and Mitochondria Cannot Be Separated

Dr. LeBon's foundational biological analogy: NAD+ is the crude oil, mitochondria are the refinery, and ATP is the refined fuel. Pumping crude oil into a broken refinery will not generate power.

•ATP is the universal energetic currency required for every one of the human body's ~30 trillion cells.
•NAD+ acts as the primary electron carrier facilitating glycolysis, the Krebs cycle, and oxidative phosphorylation.
Source: Dallas1.json & Dallas2.jsonExplore Teaching
Mitochondria8 min read

Mitochondrial Quality Control: The PINK1/Parkin Tagging & Clearance Pathway

How cells identify and tag damaged, leaking mitochondria for lysosomal degradation, clearing cellular real estate so vibrant new mitochondria can be generated.

•Mitochondrial turnover is not passive; it requires active enzymatic surveillance.
•PINK1 accumulates on the outer membrane of depolarized (damaged) mitochondria.
Source: Dallas1.json & NAD_Research_Packet.pdfExplore Teaching
Molecular Purity9 min read

The Hourglass Rate-Limiting Neck: PARP, Sirtuins, SARM1, and CD38

Under metabolic strain, four vital enzyme families fight for the same dwindling pool of NAD+. Understanding the rate-limiting neck of the cellular hourglass.

•NAD+ is not merely an energy metabolite; it is consumed as a co-substrate by regulatory enzymes.
•The PARP System governs DNA repair and prevents uncontrolled chromosomal mutations.
Source: NAD_Research_Packet.pdf (Sections 2-3) & Dallas2.jsonExplore Teaching
Longevity5 min read

The 46-Year Precipice: The Sudden Demise of Cellular Energy Reserves

At age 46, NAD+ levels decline precipitously in human tissue, followed by a 60% loss of functional mitochondrial mass by age 60. Why midlife fatigue is a biological event, not a personal failing.

•Human tissue experiences an accelerated biological decline in NAD+ concentration starting around age 46.
•By age 60, approximately 60% of mitochondrial volume and efficiency is lost in skeletal muscle and organs.
Source: Dallas1.json & Dallas2.jsonExplore Teaching
Molecular Purity7 min read

Stereochemical Purity: Why Living Biology Exclusively Recognizes Beta-NAD+

The single chemical difference at the C1' ribose carbon that separates life-giving energy from biologically inert synthetic chemical powder. Yeast fermentation vs. chemical synthesis.

•Beta-NAD+ (β-NAD+) is the ONLY biologically active stereoisomer recognized by living enzymes.
•Alpha-NAD+ (α-NAD+) has the identical molecular formula but inverted 3D geometry at the C1' glycosidic bond.
Source: NAD_Research_Packet.pdf (Section 8) & Dallas2.jsonExplore Teaching
Nanotechnology7 min read

nanoNAD+™: Breaking the Aggregation Barrier Through 1.92nm Dispersion

How Molecular World Health's patent-pending nanotechnology separates clumped NAD+ molecular aggregates into uniformly dispersed single molecules (1.924 nm) confirmed by Particle Technology Labs.

•In raw aqueous solution, conventional NAD+ clumps together into bulky molecular aggregates.
•Particle Technology Labs (PTL) confirmed 1.924 nm hydrodynamic diameter (100% single-molecule volume).
Source: NAD_Reference_Packet_Aug2026.txt & PTL DLS Report (544383-88)Explore Teaching
Bioenergetics6 min read

The Precursor Paradox: Why NR and NMN Stumble Without Baseline ATP

The biochemical flaw in oral precursor supplementation: synthesizing NAD+ from NR or NMN requires ATP. When an exhausted cell is depleted of NAD+, it lacks the ATP needed to convert the precursors.

•Precursors like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are not finished NAD+.
•The enzymatic salvage pathway consumes cellular ATP to synthesize NAD+.
Source: Dallas2.json & Interview_0912_2250.jsonExplore Teaching
Longevity6 min read

The Inflammaging Cascade: How Depleted Sirtuins Accelerate Chronic Disease

As NAD+ declines, sirtuins lose the substrate needed to suppress NF-κB, igniting a chronic low-grade inflammatory fire that depletes remaining NAD+ in a destructive loop.

•Inflammaging is the chronic, sterile, low-grade systemic inflammation that characterizes aging.
•SIRT1 normally suppresses inflammatory cytokines by deacetylating the NF-κB p65 subunit.
Source: NAD_Research_Packet.pdf & Dallas2.jsonExplore Teaching
Neuroscience7 min read

Neurological Resilience: SARM1 Dendritic Pruning & The Adenosine Stress Receptor Axis

How NAD+ metabolism fuels neuronal synaptic plasticity, regulates axonal pruning via SARM1, and modulates adenosine A1/A2A receptors to dampen trauma-induced fear hyperarousal.

•Psychological trauma and stress disrupt mitochondrial oxidative phosphorylation in neurons.
•Extracellular NAD+ is metabolized into adenosine, which activates A1 inhibitory receptors to dampen amygdala hyperarousal.
Source: NAD_Research_Packet.pdf & Dallas2.jsonExplore Teaching
Nanotechnology6 min read

Dermal Bioenergetics: Overcoming Photo-Aging with Single-Molecule Topical NAD+

Extrinsic photo-damage accounts for 97% of visible skin aging by driving fibroblast senescence. How topical 1.92 nm nanoNAD+ fuels dermal cellular machinery and collagen restoration.

•Extrinsic ultraviolet radiation and environmental oxidants trigger fibroblast senescence.
•Senescent fibroblasts secrete matrix metalloproteinases (MMPs) that actively digest dermal collagen.
Source: NAD_Research_Packet.pdf & Dallas2.jsonExplore Teaching